Looking after young eye patients in hospital

Admission into hospital can be an anxious and unsettling time for a child, whether it is for a planned eye procedure or as a result of an eye injury. There is a lot you can do to make the hospital experience as positive as possible to reduce stress and anxiety for both child and parent

Real-time sweat pH monitoring based on a wearable chemical barcode micro-fluidic platform incorporating ionic liquids

This work presents the fabrication, characterisation and the performance of a wearable, robust, flexible and disposable chemical barcode device based on a micro-fluidic platform that incorporates ionic liquid polymer gels (ionogels). The device has been applied to the monitoring of the pH of sweat in real time during an exercise period. The device is an ideal wearable sensor for measuring the pH of sweat since it does not contents any electronic part for fluidic handle or pH detection and because it can be directly incorporated into clothing, head- or wristbands, which are in continuous contact with the skin. In addition, due to the micro-fluidic structure, fresh sweat is continuously passing through the sensing area providing the capability to perform continuous real time analysis. The approach presented here ensures immediate feedback regarding sweat composition. Sweat analysis is attractive for monitoring purposes as it can provide physiological information directly relevant to the health and performance of the wearer without the need for an invasive sampling approac

Supporting survivors of sexual violence:protocol for a mixed methods, co-research study of the role, funding and commissioning of specialist services provided by the voluntary sector in England

Abstract Introduction The voluntary sector provides a range of specialist services to survivors of sexual violence, many of which have evolved from grass roots organisations responding to unmet local needs. However, the evidence base is poor in terms of what services are provided to which groups of survivors, how voluntary sector specialist (VSS) services are organised and delivered and how they are commissioned. This will be the first national study on the role of the voluntary sector in supporting survivors in England. Methods and analysis This study uses an explanatory sequential naturalistic mixed-methods design with two stages. For stage 1, two national surveys of providers’ and commissioners’ views on designing and delivering VSS services will facilitate detailed mapping of service provision and commissioning in order to create a taxonomy of VSS services. Variations in the national picture will then be explored in stage 2 through four in-depth, qualitative case studies using the critical incident technique to explain the observed variations and understand the key contextual factors which influence service provision. Drawing on theory about the distinctive service contribution of the voluntary sector, survivors will be involved as co-researchers and will play a central role in data collection and interpretation. Ethics and dissemination Ethical approval has been granted by the University of Birmingham research ethics committee for stage 1 of the project. In line with the sequential and co-produced study design, further applications for ethical review will be made in due course. Dissemination activities will include case study and end-of-project workshops; good practice guides; a policy briefing; project report; bitesize findings; webinars; academic articles and conference presentations. The project will generate evidence about what survivors want from and value about services and new understanding about how VSS services should be commissioned and provided to support survivors to thrive in the long term

Combined linkage and association analysis of classical Hodgkin lymphoma

Peer reviewedPublisher PD

Reconnecting Downtown to the Riverfront. Springfield, MA. Senior Urban Design Studio,

The work of this urban design studio illustrates visions for the revitalization of Springfield’s downtown riverfront through landscape architecture facing the challenges of a dissecting I-91 highway corridor. Re-Connecting people to the riverfront capi­talizes on the great Connecticut River and will revitalize the city to attract and engage residents and visitors alike. The proposals foster creating spaces in Riverfront Park for multiple activities such as recreation, places for arts and culture, education and enhancement of the River’s ecology. They further promote pedestrian/bicycle arteries to and along the riverfront that are embedded in a livable, mixed-use, diverse neighborhood. The work explores a community service learning strategy within the framework of an urban design studio with the goal of revitalizing the city of Springfield, Massachusetts, through sustainable design, planning, and engagement with the community. This studio produced six tangible visions and are based on three scenarios; 1) Scenario 1keeps the highway I-91 on an elevated level above ground; 2) Scenario 2 lowers I-91 down to an on-ground level; 3) Scenario 3 lowers I-91 underground as a completely or partially covered corridor. All six design visions share the following recommendations and principles to create a livable and sustainable city that engages the riverfront as a place for people and as a landscape that will be crucial for a great future of Springfield’s downtown: Creating spaces in Riverfront Park that are more centered and generous for multiple activities; add floodplains to improve the ecology of the River and educate the public. Creating pedestrian/bicycle arteries from Main Street to the riverfront. Elimination of on- and off- ramps within the core of downtown to prioritize pedestrian movement to the Connecticut River and reduce noise. Eliminate parking structures underneath the highway for visibility of the River. Redesigning East and West Columbus Avenue as pedestrian- and bicycle-friendly corridors through a road diet and speed reduction. Foster mixed-use development along East Columbus Avenue at the edge of the South End Neighborhood. Connect the Connecticut River Walk and Bikeway to Forest Park in the south

Green Infrastructure for Framingham, Massachusetts: Greenway Planning and Cultural Landscape Design

The senior undergraduate, Bachelors of Landscape Architecture studio at the University of Massachusetts, Amherst developed a town-wide greenway plan for the Town of Framingham’s Department of Community and Economic Development. This conceptual plan connects the town’s natural, cultural, and recreational resources through a network of pedestrian and bike trails. This plan also seeks to connect the diverse neighborhoods within the Town to these resources and provide alternative means of local residents to access jobs, schools, and retail centers. The greenway plan builds on Framingham’s Open Space and Recreation Plan (2013), which identified the need for a regional greenway system to link the town to the many local and regional recreational, cultural, ecological, and economic resources. This capstone planning and design studio began with an analysis and assessment of the Town of Framingham’s natural, recreational, cultural, and transportation/land use resources. Teams of students developed alternative greenway plans for the town and region, respectively. These plans were synthesized halfway through the class to produce the composite greenway plan shown in this report. For the second half of the class, individual students developed neighborhood and site specific greenway and park designs for key linkages within the greenway network in the rural northeast section of Framingham, industrial village of Saxonville, historic Framingham Center, the Tech Park, and downtown Framingham. These detailed designs form the body of this report

Development and validation of a clinical prediction rule for development of diabetic foot ulceration: an analysis of data from five cohort studies.

Introduction The aim of the study was to develop and validate a clinical prediction rule (CPR) for foot ulceration in people with diabetes. Research design and methods Development of a CPR using individual participant data from four international cohort studies identified by systematic review, with validation in a fifth study. Development cohorts were from primary and secondary care foot clinics in Europe and the USA (n=8255, adults over 18 years old, with diabetes, ulcer free at recruitment). Using data from monofilament testing, presence/absence of pulses, and participant history of previous ulcer and/or amputation, we developed a simple CPR to predict who will develop a foot ulcer within 2 years of initial assessment and validated it in a fifth study (n=3324). The CPR’s performance was assessed with C-statistics, calibration slopes, calibration-in-the-large, and a net benefit analysis. Results CPR scores of 0, 1, 2, 3, and 4 had a risk of ulcer within 2 years of 2.4% (95% CI 1.5% to 3.9%), 6.0% (95% CI 3.5% to 9.5%), 14.0% (95% CI 8.5% to 21.3%), 29.2% (95% CI 19.2% to 41.0%), and 51.1% (95% CI 37.9% to 64.1%), respectively. In the validation dataset, calibration-in-the-large was −0.374 (95% CI −0.561 to −0.187) and calibration slope 1.139 (95% CI 0.994 to 1.283). The C-statistic was 0.829 (95% CI 0.790 to 0.868). The net benefit analysis suggested that people with a CPR score of 1 or more (risk of ulceration 6.0% or more) should be referred for treatment. Conclusion The clinical prediction rule is simple, using routinely obtained data, and could help prevent foot ulcers by redirecting care to patients with scores of 1 or above. It has been validated in a community setting, and requires further validation in secondary care settings